Austin Pathology

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Anti-Neuronal Antibodies (CSF)

Alternate Names
Anti Neuronal Antibodies, Paraneoplastic Antibodies, ANNA-1, Anti-Hu, ANNA-2, Anti-Ri, Anti-PCA-1, Anti-Yo, Anti-PCA-2, Anti-CV2, CRMP5, Anti-PCA-Tr, Anti-Ma, Anti-Ta, Anti-GAD, Anti-amphiphysin, Anti-DPPX, DPPX, Neuronal Ab
Test Code
NEURAB
Testing Laboratory
Referred Laboratory
Specimen Type

CSF

Container Type

Sterile CSF Tube

Medicare Rebate

Yes

Out of Pocket Costs
None
Ordering Information

If specific neuronal antibodies are desired, please specify these on the request form. Otherwise, general requests will be screened for most common antibodies.

Screening for neuronal antibodies will be performed via indirect immunofluorescence. If screening is positive, additional specificities will be performed (see below):

  • ANNA-1/anti-Hu
  • ANNA-2/anti-Ri
  • Anti-PCA-1/anti-Yo
  • Anti-PCA-2
  • Anti-CV2/CRMP5
  • Anti-PCA-Tr
  • Anti-Ma/Ta
  • Anti-GAD
  • Anti-amphiphysin
  • Anti-DPPX

Note: This test is strongly advised to be performed on both CSF and serum to optimise sensitivity and specificity. Consider combining with Autoimmune Encephalitis Screen testing if indicated.

Collection Instructions

CSF samples should be sent to the laboratory immediately. Ensure all caps are screwed on correctly to avoid leakage.

Transport Instructions
Transport ambient at room temperature
Storage Instructions
Store refrigerated at 4°C
Testing Frequency
Monthly
Min Test Volume
1mL
Add On Test Suitability

Refrigerated (2 - 4°C) 

up to 3 months*

Frozen Plasma (-20°C) 

up to 3 months* 


*Subject to sample availability

Container ID
CSF4,CSF1,CSF2,CSF3,CR,CRS,CB,CBS
CSR Instructions

Instructions for: Regional Specimen Receptions

  • Forward specimens frozen to the Heidelberg laboratory.
Laboratory Instructions

Instructions for: Metropolitan & Regional Specimen Receptions

CSF samples should be handled urgently.

Where there are multiple tubes from a lumbar puncture:

  • Tube 3 is for Microbiology and 1, 2 for Biochemistry, Cytology, etc. (If tube 3 is not available for Microbiology, send tube 2)
  • If tap is traumatic (blood-stained), 1 and 3 go to Microbiology for cell counts.

 If insufficient tubes are received for the tests requested, please contact the Medical Microbiologist or Registrar

External Laboratory
Immunology, Royal Brisbane & Women's Hospital
Accredited Test
Yes