Austin Pathology

Test Directory

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Alternate Names
Ordering Information

A record of dietary salt intake and/or administration of diuretics or vasodilator drugs should be included on the request form. 

Aldosterone, plasma renin concentration and their ratio (ARR) must be interpreted in the context of medications and electrolyte status. For guidance on patient preparation, medications, and result interpretation, click here or contact Chemical Pathologist (03) 9496 5140

For upright requests, collect blood mid-morning (9 - 10 am) from seated patients who have been upright (sitting, standing or walking) for 2 to 4 hours.  

For supine requests, the patient should be lying down for at least 6 hours.

Cerner Test Name
MBS Number
EDTA (purple)
Collection Instruction
Collect at room temperature
Additional Collection Instructions

Instructions for: Metropolitan and Regional Collection Centres

  • Please collect DEDICATED EDTA (purple) tube. 
  • Collect and send to the laboratory at room temperature. 
Minimum Adult Volume
Minimum Paediatric Volume

Cooling of samples below room temperature may cause cryo-activation of Pro-Renin and can lead to falsely elevated results.

Twice per week
Reference Interval
 Reference Interval
Upright Aldosterone concentration < 978 pmol/L
Supine Aldosterone concentration < 654 pmol/L
Aldosterone: Renin Ratio < 70

Note Aldosterine:Renin ratio (ARR) for the purpose of screening for Primary Hyperaldosteronism: RI <70

An ARR ≥ 70 should be repeated, taking into consideration any interferring medications. If positive again on the second occasion further investigation for Primary Hyperaldosteronism should be considered. It is important to understand that cut-off values may vary even between laboratories using the same testing method, depending on the patient population tested and the sensitivity/specificity desired. In general, lower cut-offs (e.g. around 30) will offer high sensitivity at the expense of specificity while higher cut-offs (e.g. 100) are more specific for primary hyperaldosteronism but may miss milder cases. Clinicians should be aware of the limitations of this cut-off.

Test Code
Container ID
Additional (Storage) Instructions

Instructions for: Metropolitan and Regional Specimen Receptions

  • Plasma aliquots should preferrable by frozen at -80°C, however -20°C is acceptable.
  • Whole blood samples should be stored at room temperature.
Transport Instructions
Transport separated and frozen at -20°C
Transport at room temperature
Additional Transport Instruction

Instructions for: Metropolitan and Regional Specimen Receptions

  • Once frozen, aliquots may be transported at -20°C.
  • Whole blood samples must be transported at room temperature.
Laboratory Notes

Instructions for: Metropolitan and Regional Specimen Receptions

  • Centrifuge, aliquot, and snap freeze within 8 hours of collection.