Austin Pathology

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Renin Concentration

Ordering Information

A record of dietary salt intake and/or administration of diuretics or vasodilator drugs should be made on the request form. 

Aldosterone, plasma renin concentrationand their ratio (ARR) must be interpreted in the context of medications and electrolyte status. For guidance on patient preparation, medications, and result interpretation, click here or contact Chemical Pathologist (03) 9496 5140

Add-on tests for Renin cannot be done on a previous sample which has been collected and/or stored at 4 Deg C.

 

 

Laboratory
Biochemistry
Specimen
Blood
Container
EDTA (purple)
Collection Instruction
Collect at room temperature
Additional Collection Instructions

**IMPORTANT**

If specimens are collected from a location external to Austin Pathology, they should be spun and the plasma frozen at -80 degrees Celcius. Please note that freezing at -20 degrees is NOT sufficient and may cause cryo-activation of pro-renin leading to falsely high results.

Once frozen at -80 degrees, samples can be transferred to, or transported at, -20 degrees.

Minimum Adult Volume
4mL
Minimum Paediatric Volume
None
Notes

Renin and Aldosterone tests if ordered at the same time, can be collected into the same EDTA tube.

Plasma must be frozen (-80 degrees Celcius*) within 6 hours of collection.  Sample cannot be refrozen once thawed. 

*Freezing at -20 degrees Celcius is NOT sufficient.



Frequency
Once a week
Reference Interval

Spot Renin & Upright concentration 

4.4 - 46.1 mIU/L
Supine Renin concentration 2.8 - 39.9 mIU/L

Aldosterone:Renin Ratio

< 70

ARR >/= 70 should be repeated. If positive again on the second occasion, further investigation for Primary Hyperaldosteronism should be considered.
It is important to understand that cut-off values may vary even between laboratories using the same testing method, depending on the patient population tested and the sensitivity/specificity desired.
 In general, lower cut-offs (e.g. around 30) will offer high sensitivity at the expense of specificity while higher cut-offs (e.g. 100) are more specific for primary hyperaldosteronism but may miss milder cases. Clinicians should be aware of the limitations of this cut-off.