Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common inheritable cause of stroke in patients before the age of 65. It is caused by mutations in the NOTCH3 gene. In addition to strokes, the clinical phenotype of CADASIL may include migraine, cognitive decline and psychiatric symptoms. It is recommended that patients be seen by a genetics service or specialist prior to requesting.
