IgD levels are usually requested in patients suspected of having hyper-IgD syndrome. This rare, autosomal recessive condition is generally seen in children from an early age and is characterised by recurrent fevers, lymphadenopathy, abdominal pain, and elevated IgD levels. Classic HIDS is due to mutation in the mevalonate kinase gene.
IgD is not recommended for screening in rare, IgD myeloma; in that scenario, electrophoresis (EPG) and immunofixation (IFE) should be requested for diagnosis.
Importantly, IgD should not be used for immunodeficiency screening.
This test is a referred test. Please discuss the clinical indication with the Immunopathologist for approval.
