Austin Pathology
Test Directory
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Adalimumab
Alternate Names
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Humira Level
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Ordering Information
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Adalimulab therapeutic monitoring performed by Sullivan Nicolaides Pathology. Please ensure Medicare assignment is signed by patient, otherwise patient may receive an invoice. Note: Patients with a negative ADL level (<= 0.4 ug/ml) will be tested for anti-ADL antibodies. There may be an out-of-pocket charge for this test. |
Laboratory
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Referred Test
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Specimen
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Blood
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Container
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Serum tube (gold top)
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Minimum Adult Volume
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5mL
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Minimum Paediatric Volume
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None
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Frequency
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Once a week
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Reference Interval
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Adalimumab (ADL) levels of 5 ug/ml have been suggested as a cut-off for likelihood of clinical remission in IBD. If the patient has an ADL level of >5ug/ml with active disease, this suggests ADL drug resistance. If ADL levels are <5ug/ml with positive anti-ADL antibodies, suggest therapy be changed. Adalimumab levels <5 ug/ml are associated with poorer improvement in DAS28 scores in RA. ADL Assay Ranges: Anti-ADL Ranges: In the setting of active IBD: If ADAL level: subtherapeutic and Anti-ADAL: low or neg If ADAL level: subtherapeutic and Anti-ADAL: High If ADAL level: Therapeutic but not responding, (Anti-ADAL not required) |
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