Myeloid Gene Mutation Analysis (could also be requested individually or as a MPN - Myeloproliferative Neoplasm - panel) for the following genes:
ASXL1, BRAF, CALR, CBL, CEBPA, CSF3R, CXCR4, DDX41, DNMT3A, ETNK1, EZH2, FBXW7, FLT3, GATA1, GATA2, IDH1, IDH2, JAK2, KIT, KRAS, MPL, MYD88, NOTCH1, NPM1, NRAS, PPM1D, PTEN, RHOA, RUNX1, SETBP1, SF3B1, SRSF2, STAT3, STAT5B, STAT6, TET2, TP53, U2AF1, WT1
The myeloid NGS panel simultaneously detects mutations in 39 genes important for diagnostic, prognostic or therapeutic decisions in myeloid malignancies.
The MPN Myeloproliferative Neoplasm panel simultaneously detects mutations in 8 genes:
ASXL1, CALR, CSF3R, JAK2, KIT, MPL, IDH1, IDH2
To order, use the Molecular Haematology Request form (pricing included): Molecular Haematology Test Request Form V11
Any specific FLT3 or NPM1 requests must add test code AFLTNP.
If NPM1 MRD (Minimal Residual Disease) is requested this is referred to Alfred Hospital using NPM1 test code and must be received by the external laboratory within 48 hours of collection.
For JAK2 exon 14 requests use test code AJAK2, unless JAK2 exon 12 stated then use test code AMYNGS.
Note that some of these genes are also tested using the solid tumour NGS panel for colo-rectal cancer, lung cancer or melanoma.
