Austin Pathology

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Myeloid NGS Panel (Blood)

Alternate Names
Myeloid NGS, AMYNGS, ASXL1, BRAF, CALR, CBL, CEBPA, CSF3R, CXCR4, DDX41, DNMT3A, ETNK1, EZH2, FBXW7, FLT3, GATA1, GATA2, IDH1, IDH2, JAK2, KIT, KRAS, MPL, MYD88, NOTCH1, NPM1, NRAS, PPM1D, PTEN, RHOA, RUNX1, SETBP1, SF3B1, SRSF2, STAT3, STAT5B, STAT6, TET2, TP53, U2AF1, WT1, MPN
Test Code
AMYNGS
Testing Laboratory
Molecular Diagnostics - Genetics
Specimen Type

Blood

Container Type

4 mL EDTA (Purple Top) - DEDICATED

Container Image
Medicare Rebate

No - please complete Patient Financial Consent Form.pdf

Out of Pocket Costs

Please note: Medicare Rebate for this test is subject to conditions. Patients may receive an invoice:

Myeloid NGS Panel

  • Fully covered by Medicare - MBS 73447
  • Non-Medicare eligible - $829.20

Myeloproliferative Neoplasm (MPN) NGS Panel

  • MBS 73398
  • Non-Medicare eligible- $500.00

Primary Myelofibrosis (MF), transplant eligible NGS Panel

  • Fully covered by Medicare - MBS 73399
  • Non-Medicare eligible - $700.00

 

Fee above is an indication only; please contact testing laboratory for up-to date cost. 

Ordering Information

Myeloid Gene Mutation Analysis (could also be requested individually or as a MPN - Myeloproliferative Neoplasm - panel) for the following genes:

ASXL1, BRAF, CALR, CBL, CEBPA, CSF3R, CXCR4, DDX41, DNMT3A, ETNK1, EZH2, FBXW7, FLT3, GATA1, GATA2, IDH1, IDH2, JAK2, KIT, KRAS, MPL, MYD88, NOTCH1, NPM1, NRAS, PPM1D, PTEN, RHOA, RUNX1, SETBP1, SF3B1, SRSF2, STAT3, STAT5B, STAT6, TET2, TP53, U2AF1, WT1

The myeloid NGS panel simultaneously detects mutations in 39 genes important for diagnostic, prognostic or therapeutic decisions in myeloid malignancies. 

The MPN Myeloproliferative Neoplasm panel simultaneously detects mutations in 8 genes:

ASXL1, CALR, CSF3R, JAK2, KIT, MPL, IDH1, IDH2

To order, use the Molecular Haematology Request form (pricing included): Molecular Haematology Test Request Form V13.

Any specific FLT3 or NPM1 requests must add test code AFLTNP.

If NPM1 MRD (Minimal Residual Disease) is requested using ANPM1 test code, sample must be received within 48 hours of collection.

For JAK2 exon 14 requests use test code AJAK2, unless JAK2 exon 12 stated then use test code AMYNGS.

Note that some of these genes are also tested using the solid tumour NGS panel for colo-rectal cancer, lung cancer or melanoma.

Collection Instructions

BLOOD

  • A DEDICATED 4 mL EDTA tube must be collected and should not be shared with other tests of the same sample type.

Instructions for: External Referring Laboratories

  • If DNA is the preferred specimen type, a minimum of 20μL at 50ng/μL is required.
Transport Instructions
Transport ambient at room temperature
Storage Instructions
Store refrigerated at 4°C
Testing Frequency
As Required
Min Test Volume
4mL
Add On Test Suitability

Contact Molecular Diagnostics - Genetics on 03 9496 5657 to confirm add on suitability.

Container ID
CMOL, CMOLS, EWL, EW
CSR Instructions

WHOLE BLOOD SPECIMEN - DO NOT CENTRIFUGE.

Instructions for: Metropolitan & Regional Specimen Receptions

  • For JAK2 Exon 12 mutation requests use the test code AMYNGS.
  • The JAK2 Exon 14 mutation is more commonly requested and is registered using the test code AJAK2.
  • Please check request for correct test as they have different specimen storage and transport instructions.

Instructions for: Regional Specimen Receptions

  • All whole blood samples should be transported to the Heidelberg Laboratory at 4°C.

Instructions for: Heidelberg Specimen Reception

  • Place sample in the Molecular bucket in the CSR walk-in fridge.
Laboratory Instructions
None
Accredited Test
Yes