Austin Pathology

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Xanthochromia CSF

Ordering Information

“Xanthochromia” refers to the yellow colour of CSF due to the presence of bilirubin. The presence of bilirubin in the CSF may indicate a bleed e.g. subarachnoid haemorrhage (SAH)

Austin Pathology offers determination of CSF xanthochromia by spectrophotometry.

FOR OPTIMAL RESULTS:

  • Perform LP at least 12 hours after the onset of symptoms
  • The last tube should be dedicated for xanthochromia analysis. If other tests are required, this may mean collecting a 4th tube.
  • Protect the tube from light immediately e.g. by wrapping tube in foil.
  • Transport the tube immediately to the laboratory by foot – do not send via pneumatic chute.
  • A serum sample for serum Bilirubin and Total Protein measurement should be collected at the same time as this may be required in difficult interpretations.

 A guide to interpretation may be found here.

Laboratory
Biochemistry
Specimen
CSF
Container
Sterile CSF tube
Collection Instruction
Protect from light - wrap in foil
Minimum Adult Volume
1mL
Minimum Paediatric Volume
None
Notes

Insufficient samples cannot be analysed. Please ensure enough sample volume.

Frequency
As required
Reference Interval

Net Bilirubin Absorbance (NBA) or adjusted Net Bilirubin Asorbance (ANBA) less than or equal to 0.007 AU is considered NEGATIVE for xanthochromia.