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Mycophenolic Acid - Total, Estimated Area Under the Curve, 0 - 12 hr

Alternate Names
Mycophenolate AUC, MPA AUC, MPA Mofetil, MMF, CellCept, Sodium Mycophenolate, Myfortic
Laboratory
Clinical Pharmacology
Specimen
See collection instructions
Container
EDTA (purple)
Collection Instruction
Collect on ice
Additional Collection Instructions

Complete collection instructions are available on specific forms (see 'notes' section below), a completed copy of which MUST accompany the samples.

Collection involves four samples of 4 mL into EDTA tubes - for Oral dosing collect pre-dose and +1 hr, +2 hr, +4 hr post dose, for IV infusion collect pre-dose +2 hr, +4 hr, +6 hr post start of infusion.  Transport to the laboratory on ice. 

Record on the tube labels and on the MPA AUC Sample Collection Form, the exact time of the dose and of the specimen collections along with other required details.

Referring laboratory is to collate and send the 4 samples of frozen plasma from one patient together as a set-of-four. Do not send single samples individually.

Minimum Adult Volume
None
Minimum Paediatric Volume
None
Notes

A specific MPA AUC Sample Collection/Instruction Form exists for the collection of the four samples for each type of dosing (one for Oral and one for IV infusion). Download the appropriate form from a link below.

Oral form: Collection Form MPAAUC_Oral

IV form: Collection Form MPAAUC_IV

In addition, a specific form for six-point collections (for the needs of a particular unit only) can be downloaded from the link below.

Oral 6-point/paediatric from: Collection Form MPAAUC Oral 6-point

  

Contact: Clinical Pharmacology lab: 9496 5586 / 9496 3220.

Frequency
At least once a week
Reference Interval
In renal and cardiac transplant recipients an AUC 0 - 12 hr of 30 - 60 mg.hr/L in the initial phase after transplantation has been shown to associate with less rejection.