Mycophenolic Acid - Total, Estimated Area Under the Curve, 0 - 12 hr Test | Austin Pathology

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Mycophenolic Acid - Total, Estimated Area Under the Curve, 0 - 12 hr

Alternate Names	Mycophenolate AUC, MPA AUC, MPA Mofetil, MMF, CellCept, Sodium Mycophenolate, Myfortic
Laboratory	Clinical Pharmacology
Specimen	See collection instructions
Container	EDTA (purple)
Collection Instructions	Collect on ice
Additional Collection Instructions	Complete collection instructions are available on specific forms (see 'notes' section below), a completed copy of which MUST accompany the samples. Collection involves four samples of 4 mL into EDTA tubes - for Oral dosing collect pre-dose and +1 hr, +2 hr, +4 hr post dose, for IV infusion collect pre-dose +2 hr, +4 hr, +6 hr post start of infusion. Transport to the laboratory on ice. Record on the tube labels and on the MPA AUC Sample Collection Form, the exact time of the dose and of the specimen collections along with other required details. Referring laboratory is to collate and send the 4 samples of frozen plasma from one patient together as a set-of-four. Do not send single samples individually.
Minimum Adult Volume	None
Minimum Paediatric Volume	None
Notes	A specific MPA AUC Sample Collection/Instruction Form exists for the collection of the four samples for each type of dosing (one for Oral and one for IV infusion). Download the appropriate form from a link below. Oral form: Collection Form MPAAUC_Oral IV form: Collection Form MPAAUC_IV In addition, a specific form for six-point collections (for the needs of a particular unit only) can be downloaded from the link below. Oral 6-point/paediatric from: Collection Form MPAAUC Oral 6-point Contact: Clinical Pharmacology lab: 9496 5586 / 9496 3220.
Frequency	At least once a week
Reference Interval	In renal and cardiac transplant recipients an AUC 0 - 12 hr of 30 - 60 mg.hr/L in the initial phase after transplantation has been shown to associate with less rejection.

These PDF documents can be downloaded for your reference

Order of Draw (PDF)

Swab Collection Guide (PDF)

Pre-Transfusion Specimen Requirements (PDF)

Requirements for Pathology Service (PDF)

Test Code	MPAA, or MPAAIV
Opt. Container	EDTA (purple)
Storage Instructions	Store frozen at -20°C
Additional (Storage) Instructions	Samples for a given patient collected internal at Austin Health should be centrifuged, aliquotted and then frozen. Samples for a given patient collected external to Austin Health should be sent together as a set (of frozen plasma samples), do not send samples individually.